Author/Editor		Jagodic, M; Vrhovec, I; Borštnar, S; Čufer, T
Title		Prognostic and predictive value of cathepsins D and L in operable breast cancer patients
Type		članek
Source		Neoplasma
Vol. and No.		Letnik 52, št. 1
Publication year		2005
Volume		str. 1-9
Language		eng
Abstract		None of the established prognostic factors in breast cancer (BC) is able to determine the final outcome with certainity. Tumor biological factors involved in tumor invasion and metastasis, such as cathepsins and proteins of u-PA system, have been put forward in the recent literature as strong novel prognostic factors in BC. We therefore evaluated prognostic and predictive value of cathepsin-D (CD) and cathepsin-L (CL) in 715 operable BC patients. CD and CL were determined in tumor extracts using immunoradiometric and ELISA assays, respectively. During follow-up (median 37 months), 151 (21%) patients relapsed. In a multivariate analysis of disease-free survival (DFS), CL (p=0.04), nodal status (p<0.001) and hormone receptor status (p<0.001) were the only independent significant prognostic factors. CL thus provided independent prognostic information on DFS and could also predict a response to adjuvant chemotherapy (ChT), while CD had no significant prognostic and predictive impact.
Descriptors		BREAST NEOPLASMS CATHEPSINS PREDICTIVE VALUE OF TESTS PROGNOSIS NEOPLASM STAGING DISEASE-FREE SURVIVAL