Author/Editor		Bratanič, Borut
Title		Novejša spoznanja o zaščitni funkciji ženskega mleka
Translated title		Recent data about protective function of human milk
Type		članek
Source		In: Bratanič B, editor. Zbornik prispevkov 4. simpozij z mednarodno udeležbo Dojenje, več kot hranjenje; 2005 sept 30 - okt 1; Laško. Ljubljana: Unicef Slovenija, Nacionalni odbor za spodbujanje dojenja,
Publication year		2005
Volume		str. 70-9
Language		slo
Abstract		Human milk contains a large number of components which help protect the breastfed infant against infection. In this review article the less known and new data about the composition and function of basic defence re substances in human milk are described according to professional and scientific references. The innate and adaptive immune systems are described and the function of the entero-mammaric link in breastfed infants is depicted. Among the protein protective molecules in human milk there are secretory immunoglobulins A, lactoferrin, multimeric alpha-lactoglobulin which in the form of HAMLET could kill cancer cells. Protective functions have also the milk lysozyme, several kinds of cytokines, transforming growth factor beta, interleukins, tumor necrosis factor alfa, defensins, several hormones, leptin, carbohydrate components in the form of the oligosacchardies which consist of various combinations of the five different monosaccharides-glucose, fucose, galactose, N-actykglucosamine and sialic acid. There are also lipids and the membranes of milk fat globules carrying mucin and secretory immunoglobulins. A included into protection of infants. During the first days of lactation, human milk contains relatively high numbers of live activated macrophages, neutrophils and lymphocytes. They spontaneously produce cytokines and several other mediators of immunity. The milk lymphocytes are mainly T cells and these may transfer immunological information and protective capacity to a breastfed child.
Descriptors		BREAST FEEDING MILK, HUMAN IMMUNITY, MATERNALLY-ACQUIRED