Author/Editor		Preradović, Miloje; Savanović, Vlado; Lazarov, Angel; Mihajlović, Marija
Title		Neurohumoralni status depresija
Type		članek
Source		Vojnosanit Pregl
Vol. and No.		Letnik 50, št. 4
Publication year		1993
Volume		str. 379-85
Language		ser
Abstract		In 66 patients with endogenous depression (34 males and 32 females) the concentrations of biogene amine metabolites (vanilmandelic acid (VMA), 5-hydroxyindole acetic acid (5-HIIA), adrenaline and noradrenaline) were examined in 24-hrs urine and hormon in the serum: iodothyronine (T-3), thyroxine (T-4), thyroglobuline (Tg), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), cortisol, prolactin and growth hormones. The examination was performed prior to the initiation of antidepressant therapy and 30 days after its application. The biogene amine metabolites were in reference values before initiation of the therapy, although values of 5-HIIA in women and were closer to the lower limit. Thirty days after the initiation of the antidepressant therapy the statistically significant difference was found at the level of p<0.05 for adrenalin in men and for VMA and 5-HIIA in women. The hormone values before initiation of the therapy showed increased values of growth hormone, cortisol in men and of thyroglobuline, growth hormone and cortisol in women. At the end of the antidepressant therapy the statistically significant difference was found at the level of p<0.05 for thyroglobuline and TSH in men and for thyroglobuline, growth hormone and cortisol in women. By comparing the results obtained before and after the antidepressant therapy, the siatistically significant difference was found at the level of p<0.05 for Tg in men and for Tg, T-3, prolactin and growth hormone compared to the women. It has been concluded that in patients with endogenous depression the important role in pathonenesis of the disease have some neurobiogenic disorders.
Descriptors		DEPRESSIVE DISORDER VANILMANDELIC ACID EPINEPHRINE NOREPINEPHRINE HYDROXYINDOLEACETIC ACID GROWTH SUBSTANCES PROLACTIN TRIIODOTHYRONINE THYROXINE THYROGLOBULIN HYDROCORTISONE THYROTROPIN CORTICOTROPIN ANTIDEPRESSIVE AGENTS