Author/Editor		Takač, I; Arko, D; Bali, R; Bosilj, D; Čas-Sikošek, N; Ognjenovik, D; Gorišek, B; Kodrič, T; Zukanović, D
Title		Diagnostični pomen testa HPV po zdravljenju CIN in izsledki slovenskih raziskav
Translated title		Diagnostic value of HPV testing after CIN treatment: Slovene research data
Type		članek
Source		In: Možina A, editor. HPV in preprečevanje raka materičnega vratu: kje smo in kako naprej?: mednarodni znanstveni simpozij; 2005 okt 7; Ljubljana. Ljubljana: Združenje za ginekološko onkologijo, kolposkopijo in cervikalno patologijo,
Publication year		2005
Volume		str. 43-56
Language		slo
Abstract		Background. Human papilloma virus (HPV) is usually eradicated after treatment of cervical intraepithelial neoplasia (CIN) indicating causal therapy. The negative predictive value of a negative HPV test is very high since a negative HPV test almost eacludes CIN persistence or recurrence. This is also true after incomplete resection of CIN. Sensitivity of a HPV test with regard to detection of CIN recurrence is high. Methods. On the basis of prospective collected data from 38 patients with CIN, in which reconization was performed at the Department of Gynecologic and Breast Oncology of Maribor Teaching Hospital in the period from 1.1.1999 to 31.12.2004, their infection with high risk HPV types was analyzed. Results. In the observation period reconization was performed in 6.5% of patients. Before reconization, 21 patients (55.3%) were infected with high-risk HPV and 17 patients (44.7%) were HPV negative. Among HPV negative patients, two (11.8%) had CIN 1, five (29.4%) CIN 2, nine (52.9%) CIN 3 and one patient (5.9%) had microinvasive cancer of the uterine cervix. Conclusions. On the basis of study results we cannot recommended the HPV test as the only method of detection of residual or recurrent CIN after conization, The combination of cytology and HPV testing increases the safety of follow-up after CIN therapy. The conclusions, however, are preliminary because of missing prospective and controlled trials.
Descriptors		CERVICAL INTRAEPITHELIAL NEOPLASIA PAPILLOMAVIRUS, HUMAN CONIZATION IN SITU HYBRIDIZATION REOPERATION