| Author/Editor | Trošt, Maja | |
| Title | Proučevanje sprememb možganske presnove s pozitronsko izsevno tomografijo pri bolnikih z motnjami gibanja | |
| Translated title | Brain metabolism changes in movement disorders patients studied with positron emission tomography | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2005 | |
| Volume | str. 109 | |
| Language | slo, eng | |
| Abstract | Movement disorders are often caused by disfunction of basal ganglia and their connections. Fuuctional brain imaging enables quantitative and in vivo measurements of metabolic and neurochemical changes in the brain and therefore an insight into brain function in normal subjects and patients. In my PhD thesis I used the functional brain imaging method-positron emission tomography (PET) with radioligand (18F)-fluorodeoxyglucose (FDG) to study metabolic brain changes in patients with different movement disorders: dystonia, posthypoxic myoclonus and Parkinson's disease (PD). In PD patients I followed and compared metabolic effects of two neuro-surgical therapies: subthalamotomy, and deep brain stimulation (DBS) of subthalamic nucleus (STN). Dystonia is a movement disorder with a complex and not fully understood pathophysiology. A disfunction in different levels of central and peripheral nervous system has been studied apart from striatum. Recent studies using electrophysiology, biochemistry getics and functional brain imaging have provided new insights into the pathophysiology of dystonia which enables new ways of treatment. A specific abnormal pattern of brain metabolism has been identified in primary dystonia using network analysis of PET scans. This pattern is not present in secondary dystonia. In patients with another hyperkinetic movement disorder - posthypoxic myoclonus (PHM), we have identified a significantly increased brain metabolism bilaterally in the ventrolateral thalamus and pontine tegmentum, relative to healthy subjects. We believe that thalamus and pons are involved in PHM generation. Surgical interventions of these nuclei may be a way of treatment for severe PHM cases. In recent years, neuro-surgical treatment of PD has been reintroduced due to drawbacks of drug treatment and technical improvements. (Abstract truncated at 2000 characters) | |
| Descriptors | MOVEMENT DISORDERS BRAIN TOMOGRAPHY, EMISSION-COMPUTED DYSTONIA MYOCLONUS PARKINSON DISEASE |