Author/Editor		Berginc, Gašper; Glavač, Damjan
Title		Microsatellite instability and loss of heterozygosity as clinically important molecular markers in different tumours
Translated title		Mikrosatelitna nestabilnost in izguba heterozigotnosti kot klinično pomembna molekularna označevalca pri različnih tumorjih
Type		članek
Source		In: Luzar B, Poljak M, Glavač D, et al, editors. Molekularna diagnostika v medicini. Zbornik 15. spominsko srečanje akademika Janeza Milčinskega, 36. memorialni sestanek profesorja Janeza Plečnika, 1. srečanje Slovenskega društva za humano genetiko z mednarodno udeležbo; 2005 30 nov - 2 dec; Ljubljana. Ljubljana: Medicinska fakulteta,
Publication year		2005
Volume		str. 255-62
Language		eng
Abstract		Tumours develop through a microsatellite instability pathway linked with mutator phenotype and chromosome instability pathway associated with large chromosomal abnormalities. Certain molecular markers far the detection of tumour development through both pathways are being intensely investigated in order to provide clinically valuable information in addition to that provided by standard histopathological methods. Various microsatellite markers are used in the analysis of microsatellite instability and loss of heterozygosity in order to detect the mutator phenotype and allelic losses. Specific molecular events detected with the aforementioned methods are associated with different tumours and help clinicians to decide about treatment and prognosis. Here we describe some tumours (colorectal cancer, endometrial cancer, neuroblastoma, meningioma, oligodendroglioma) in which microsatellites have proved to be successful predictors of the disease course, tumour stage, recurrence, and treatment response.
Descriptors		NEOPLASMS MICROSATELLITE REPEATS HETEROZYGOTE COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS NEUROBLASTOMA MENINGIOMA PROGNOSIS