Author/Editor		Matos, Tadeja
Title		Molecular diagnostics of medical important yeasts and moulds
Translated title		Molekularna diagnostika medicinsko pomembnih gliv in plesni
Type		članek
Source		In: Luzar B, Poljak M, Glavač D, et al, editors. Molekularna diagnostika v medicini. Zbornik 15. spominsko srečanje akademika Janeza Milčinskega, 36. memorialni sestanek profesorja Janeza Plečnika, 1. srečanje Slovenskega društva za humano genetiko z mednarodno udeležbo; 2005 30 nov - 2 dec; Ljubljana. Ljubljana: Medicinska fakulteta,
Publication year		2005
Volume		str. 431-8
Language		eng
Abstract		Invasive fungal infection, especially in immunocompromised patients, can result in life-threatening infection. The most common fungal pathogens that cause invasive diseases are Aspergillus spp. and Candida spp. The early diagnosis of invasive fungal infection has been extremely difficult because the clinical signs and symptoms are nonspecific, which leads to a delay in the diagnosis and; consequently, a delay in the institution of appropriate antitungal therapy. Current laboratory methods for fungal detection and identification are still time-consuming and lack sensitivity and specificity. The alternative to standard laboratory diagnostic methods includes amplification and detection of specific fungal DNA sequences. Molecular methods are promising because of higher sensitivity and specificity than standard laboratory methods. Many unsolved questions will remain, before these methods are introduced in routine clinical mycology practice. One of the most important is the standardization of the methods for DNA extraction and DNA detection.
Descriptors		MYCOSES DNA, FUNGAL POLYMERASE CHAIN REACTION