Author/Editor		Pavlin, Darja; Tozon, Nataša; Pogačnik, Azra; Čemažar, Maja
Title		Elektroporacija - nov sistem za dostavljanje zdravil v celico
Translated title		Electroporation - new drug delivery system
Type		članek
Source		Vet Nov
Vol. and No.		Letnik 31, št. 5-6
Publication year		2005
Volume		str. 165-72
Language		slo
Abstract		Electroporation is a procedure which transiently increases permeability of cell membrane. By application of external electric field enables the delivery of various molecules into the cells. Structural changes in cell membrane during electroporation are still not completely understood. The effect of electroporation depends on different factors: parameters of applied electric field, physical and chemical characteristics of electroporation media and characteristics of molecules that are delivered intracellulary. Electroporation is gaining increasing importance in different fields of molecular biology, biotechnology, and human and veterinary medicine, where it is already used in clinical practice.
Summary		Elektroporacija je postopek, pri katerem z uporabo zunanjega elektricnega polja zacasno povecamo prepustnost celicne membrane in omogocimo vnos razlicnih vrst molekul v celico. Spremembe v celični membrani, ki nastanejo med elektroporacijo, zaenkrat še niso natančno pojasnjene. Na rezultat elektroporacije vplivajo različni dejavniki: lastnosti apliciranega električnega polja, fizikalne in kemijske lastnosti elektroporacijskih gojišč, lastnosti snovi, ki jih vnašamo, in lastnosti tarče. Elektroporacija pridobiva vedno večji pomen na različnih področjih molekularne biologije, biotehnologije in tudi humane ter veterinarske medicine, kjer se vse več uporablja pri kliničnem delu.
Descriptors		ELECTROPORATION DRUG DELIVERY SYSTEMS NEOPLASMS