Author/Editor		Hemminki, K; Scelo, G; Boffetta, P; Mellemkjaer, L; Tracey, E; Anderson, A; Brewster, DH; Pukkala, E; McBride, M; Pompe-Kirn, V
Title		Second primary malignancies in patients with male breast cancer
Type		članek
Source		Br J Cancer
Vol. and No.		Letnik 92, št. 7
Publication year		2005
Volume		str. 1288-92
Language		eng
Abstract		An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from I3 cancer registries. Among a total of 3409 men with primary breast cancer, 426 ( I 2.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, I.35- I2.7), rectum ( I.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, I.65, I.I6-2.29), prostate (I.61, I.34- I.93) and lymphohaematopoietic system (I.63, I.I2-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA I ) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.
Descriptors		BREAST NEOPLASMS, MALE NEOPLASMS, SECOND PRIMARY REGISTRIES AGE FACTORS FOLLOW-UP STUDIES RISK FACTORS