Author/Editor		Snoj, Marko; Rudolf, Zvonimir; Čemažar, Maja; Jančar, Boris; Serša, Gregor
Title		Successful sphincter-saving treatment of anorectal maligant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy
Type		članek
Source		Anticancer Drugs
Vol. and No.		Letnik 16, št. 3
Publication year		2005
Volume		str. 345-8
Language		eng
Abstract		Anorectal malignant melanoma is a rare tumor and there is no consensus on whether aggressive or local management is more appropriate. Local sphincter-saving excision has been shown to have a higher recurrence rate than abdominoperineal resection, although there is no long-term survival difference between the two approaches. Therefore, new adjuvant treatment strategies to permit local sphincter-saving excisions are warranted. In our case, a large anorectal malignant melanoma was successfully treated preoperatively by electrochemotherapy with cisplatin that, by reducing the tumor size, enabled sphincter-saving local excision. Brachytherapy was postoperatively delivered to the excision site. Fourteen months after the beginning of treatment, the patient is without signs of local recurrence and is continent.
Descriptors		ANUS NEOPLASMS ANTINEOPLASTIC AGENTS CISPLATIN BRACHYTHERAPY MELANOMA MIDDLE AGE TREATMENT OUTCOME