| Author/Editor | Skok, Pavel | |
| Title | Poškodbe želodčne sluznice z nesteroidnimi protivnetnimi zdravili | |
| Translated title | Injuries of gastric mucosa induced by nonsteroidal antiinflammatory drugs | |
| Type | članek | |
| Source | Gastroenterolog | |
| Vol. and No. | Letnik 9, št. 20 | |
| Publication year | 2005 | |
| Volume | str. 71-6 | |
| Language | slo | |
| Abstract | Nonsteroidal anti-inflammatory drugs have been used over many decades for treatment of inflammation and pain. Due to prostaglandin inhibition this drugs cause gastrointestinal adverse effects, disturbances of kidney function, congestive heart failure and blood coagulation. Clinically significant gastrointestinal adverse effects are mainly ulcers, hemorrhages and less often, perforalion of the digestive tube. Nonsteroidal anti-inflammatory drugs differ mainly in their potency of inhibition of two cyclooxygenase isoforms, COX 1 and COX 2. The newer class of this drugs, coxibs, have a less potent effect on prostaglandin synthesis in the gastrointestinal tract, but have unfortunately also adverse effeects. Safe use nonsteroidal anti-inflammatory drugs is based on careful selection of patients, correct intake of the prescribed drug and efficacious protection of patients with risk factors. | |
| Summary | Nesteroidna protivnetna zdravila uporabljamo že desetletja za zdravljenje vnetja in bolečine. Zaradi zaviranja prostaglandinov povzročajo neželene učinke na prebavilih, motnje v delovanju ledvic, zastojnem srčnem popuščanju in strjevanju krvi. Klinično pomembni neželeni učinki na prebavni cevi so zlasti: razjede, krvavitve in manj pogosti, predrtje stene. Med seboj se ta zdravila razlikujejo zlasti po jakosti zaviranja dveh izooblik ciikloksigenaze, COX 1 in COX 2. Sodobnejši NSAR. koksibi, imajo manjši vpliv na prostaglandine v prebavilih, a imajo žal tudi neželene učinke. Varnejša uporaba nesteroidnih protivnetuih zdravil temelji na pravilni izbiri bolnikov, pravilnem odmerjanju in uživanju teh zdravil ter ustrezni zaščiti bolnikov z dejavniki ogrožanja. | |
| Descriptors | ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL GASTRIC MUCOSA STOMACH ULCER PEPTIC ULCER HEMORRHAGE ALCOHOL DRINKING SMOKING HELICOBACTER PYLORI PEPTIC ULCER PERFORATION |