Author/Editor		Geršak, K
Title		Drugs and pregnancy
Type		članek
Source		In: Kurjak A, Chervenak FA, editors. International proceedings of the 7th world congress of perinatal medicine; 2005 Sep 21-24; Zagreb. Zagreb: Medimond, International proceedings,
Publication year		2005
Volume		str. 103-6
Language		eng
Abstract		The field of dysmorphology is the clinical recognition of structural abnormalities. When a fetal ultrasound examination reveals a structural anomaly, the first step is to determine if the anomaly is an isolated single anomaly, whether there are other ultrasound findings or there are major and minor anomalies. If several anomalies are present, they may fall into a pattern, which suggests a specific sequence, syndrome or association. Anomalies can be classified into four types of abnormal morphogenesis - malformation, deformation, disruption and dysplasia. Documenting the family history, and laboratory studies are essential in trying to determine whether the anomalies are likely to have a genetic cause. Diagnosis leading to prognostic information is especially useful in planning management and an assessment of the recurrence risk can be made. Between 2-3% of birth defects are classified as teratogen-induced malformations, which are considered to be the result of environmental or iatrogenic exposures during pregnancy. The effect of a harmful teratogenic activity is associated with the fetal genotype, the developmental stage of the fetus, and characteristics, mechanism of activity and dose of the teratogen. For potential teratogenic or otherwise harmful effects on the fetus, the FDA classification of drugs is used in Slovenia. Drugs during pregnancy are being prescribed to treat chronic maternal diseases, to treat pregnancy-induced or acute conditions, and to treat fetus as a patient. Although many medications are safe during pregnancy knowledge of each specific drug is necessary to avoid misinformation.
Descriptors		ABNORMALITIES, DRUG-INDUCED DRUG THERAPY GENOTYPE PREGNANCY