Author/Editor		Osolnik, Katarina
Title		Nonspecific interstitial pneumonia (NSIP)
Translated title		Nespecifična intersticijska pneumonija (NSIP)
Type		članek
Source		In: Peroš-Golubičić T, editor. Sarkoidoza / bolesti plućnog intersticija. Zagreb: Medicinska naklada,
Publication year		2005
Volume		str. 298-303
Language		cro
Abstract		Nonspecific interstitial pneumonia (NSIP) as a subset of idiopathic interstitial pneumonias (IIP) was first described in 1994. NSIP has better prognosis and responsiveness to therapy in comparison with usual interstitial pneumonia. NSIP histological pattern is observed in response to occupational exposures, in context of collagen vascular disorders, and other diseases of known causes but it can also be idiopathic. Since NSIP was only recently described, a lack of information in many important aspects is pointed out, including incidence, prevalence and clinical distinction of NSIP from other IIPs. Due to different prognosis between cellular and fibrotic group, histological segregation in these two groups was favorised. Most common clinical symptoms of NSIP are: breathlessness, cough, fatigue and a history of weight loss. Chest radiographic features in NSIP shows bilateral patchy alveolar and interstitial pulmonary infiltrates with more frequently involved lower lung zones. HRCT characteristic features include ground - glass opacities with or without consolidation with varying degrees of interstitial changes. The natural history and long-term prognosis o f NSIP remain to be clarified. The relationship between NSlP and UIP seems to be important due to a practical standpoint: the histological diagnosis of NSIP suggests a more favorable prognosis than UIP and supports a more aggressive therapy with corticosteroids or immunosuppressive drugs.
Descriptors		LUNG DISEASES, INTERSTITIAL THORACIC RADIOGRAPHY BRONCHOALVEOLAR LAVAGE