Author/Editor		Terzić, Rifet; Letonja, Mitja; Terzić, Ibrahim; Šehić, Amela; Merić, Muharem; Teran, Nataša
Title		Insertion/deletion polymorphism of angiotensin-converting enzyme gene - risk factor for coronary artery disease in the Tuzla region population (Bosnia and Herzegovina)
Translated title		Insercijski/delecijski polimorfizam u genu angiotenzin konvertirajučeg enzima (ACE) - čimbenik rizika bolesti koronarnih arterija u stanovništvu Tuzlanske regije (Bosna i Herzegovina)
Type		članek
Source		Coll Antropol
Vol. and No.		Letnik 27, št. 2
Publication year		2003
Volume		str. 537-40
Language		eng
Abstract		Angiotensin II is the major effector molecule of renin-angiotensin system: its production can be conveniently interrupted by angiontensin-converting enzyme (ACE). Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary artery disease (CAD) and to what extent the ACE polymorphism is associated with CAD patients younger than 50 years with 165 healthy control individuals. hey were all from the Tuzla region in Bosnia and Hercegovina. Patients with CAD had a higher prevalence of the DD genotype (36.3%) than controls (25.6%). The odds ratio for the ACE conclude that the D/D genotype of the ACE gene polymorphism is associated with an increased risk for CAD in the Bosnian population.
Descriptors		MYOCARDIAL INFARCTION ANGINA PECTORIS PEPTIDYL-DIPEPTIDASE A POLYMORPHISM (GENETICS) CORONARY ANGIOGRAPHY GENOTYPE BOSNIA-HERZEGOVINA