Author/Editor     Rozman, D; Fink, M
Title     CYP51, cholesterol and the cross-talks
Type     članek
Source     In: International proceedings of the 14th international conference on cytochromes P450, biochemistry, biophysics and bioinformatics; 2005 May 31- Jun 5; Dallas. Bologna: Mediamond,
Publication year     2005
Volume     str. 185-92
Language     eng
Abstract     Mammalian lanosterol 14alpha-demethylase (CYP51) is a cytochrome P450 that demethylates lanosterol in the cholesterol biosynthesis pathway. Even if considered as a housekeeping pathway, cholesterol biosynthesis shows tissue-specific modes of regulation due to different cross-talks. In the liver, the sterol regulatory element binding protein (SREBP) pathway seems to play a major role. However, other stimuli, such as intlammation or cAMP signaling, interfere with the SREBP pathway and co-regualate cholesterogenic genes. In endocrine tissues, such as testis or placenta, the cAMP signaling pathway has a major role in conversion of cholesterol to steroid metabolites and modulates also the transcriptional response of cholesterogenic CYP51 through cAMP responsive elements in the promoter. In addition to that, CYP51 and other choleslerogenic genes seem to be expressed in a circadian manner in the liver, indicating the existance of another level of regulation and cross-talk by the circadian genes. The entire -334/+314 region of the human CYP51 is a bi-directional promoter packed with DNA regulatory elements that respond to a variety of signals.
Descriptors     CELLS, CULTURED
TRANSFECTION
CYTOCHROME P-450
CHOLESTEROL
LANOSTEROL
CHROMOSOMES, HUMAN, PAIR 7
COMPUTATIONAL BIOLOGY
PROMOTER REGIONS (GENETICS)