Author/Editor     Kopač, M; Domanovič, D
Title     Neželeni učinki transfuzije
Translated title     Adverse effects of blood transfusion
Type     članek
Source     Slov Pediatr
Vol. and No.     Letnik 12, št. 4
Publication year     2005
Volume     str. 201-7
Language     slo
Abstract     Nowadays transfusions are usually given without complications, although some cases are accompanied by adverse effects, which are the consequence of errors at different levels of the transfusion process, the patient's immune response or other complications. In the event of any adverse effects (except localised urticaria) the transfusion must be stopped immediately and investigations carried out to determine the cause. Initially, transfusiologists attempt to answer the question whether the adverse effect of the transfusion is a consequence of intravascular or extravascular immune haemolysis or of non-immune haemolysis. ABO incompatibility can cause intravascular haemolysis, one of the worse adverse effects of transfusion, which has a high mortality rate. Immunohaematological investigations are undertaken only if the clinical picture is suggestive of immune haemolysis.
Summary     Danes potekajo transfuzije večinoma brez zapletov, v nekaterih primerih pa jih vendarle spremljajo neželeni učinki, ki so lahko posledica napak na različnih stopnjah transfuzijske verige, bolnikovega imunskega odziva ali drugih zapletov. Če pride do kakršnega koli neželenega učinka transfuzije (razen lokalizirane urtikarije), jo je potrebno takoj prekiniti in pričeti s preiskavami za razjasnitev neželenega učinka. Transfuziologi poskusijo na začetku odgovoriti na vprašanje, ali je neželeni učinek transfuzije posledica znotraj- ali zunajžilne imunske hemolize ali pa posledica neimunske hemolize. Zaradi neskladja krvne skupine ABO se lahko razvije intravaskularna hemoliza, ki z visoko smrtnostjo sodi med najhujše škodljive učinke transfuzije. Z imunohematološkimi preiskavami nadaljujejo le v primeru, če klinična slika neželenega učinka transfuzije kaže na veliko verjetnost imunske hemolize.
Descriptors     GRAFT VS HOST REACTION
DISEASE TRANSMISSION
BLOOD TRANSFUSION
HEMOLYSIS
SEPSIS
HEPATITIS, VIRAL, ANIMAL
CYTOMEGALOVIRUS