| Author/Editor | Rami, Birgit; Sumnik, Zdenek; Schober, Edith; Waldhoer, Thomas; Battelino, Tadej; Bratanič, Nina; Kuerti, Kalman; Lebl, Jan; Limbert, Catarina; Nadacsy, Laszlo | |
| Title | Screening detected celiac disease in children with type 1 diabetes mellitus: effect on the clinical course (a case control study) | |
| Type | članek | |
| Source | J Pediatr Gastroenterol Nutr | |
| Vol. and No. | Letnik 41, št. 3 | |
| Publication year | 2005 | |
| Volume | str. 317-21 | |
| Language | eng | |
| Abstract | To investigate clinical and metabolic characteristics of diabetic children with screening detected celiac disease in a multicenter case-control study. Methods: Cases: 98 diabetic patients were diagnosed as having silent celiac disease by screening with endomysial antibodies and subsequent biopsy. Controls: two controls in the same center were chosen, (stratified by age and age-at-diabetes onset) who were negative for endomysial antibodies (n=195). Height, weight, HbA1c, insulin dosage and acute complications were documented for at least 1 year of follow up. Results: Mean age of diabetes manifestation was 6.5+-4.1 years and diagnosis of celiac disease was made at 10.0+-5.4 years. Biopsy showed total or subtotal mucosal atrophy in 74 patients. The mean observation period after the diagnosis of celiac disease was 3.3+-1.9 years. Mean HbA1c levels were similar between cases and controls (8.63%+-1.45%) versus 8.50%+-1.39%; P=0.35). There was also no difference in the frequency of severe hypoglycemia, ketoacidosis and the applied insulin dosage (P=0.45). Body mass index-standard deviation score at celiac disease diagnosis (0.57+-1.24 versus 0.52+-1.07) and height-standard deviation score (0.14+-1.13 versus 0.30+-0.95) did not differ between cases and controls. After diagnosis of celiac disease, weight gain was diminished in boys with celiac disease compared with their controls (P<0.05). Female cases also had a lower body mass index than female controls (P=0.067). Conclusion: In a cohort of diabetic children, silent celiac disease had no obvious effect on metabolic control but negatively influenced weight gain. | |
| Descriptors | CELIAC DISEASE DIABETES MELLITUS, INSULIN-DEPENDENT HEMOGLOBIN A, GLYCOSYLATED HYPOGLYCEMIA DIABETIC KETOACIDOSIS CHILD INSULIN BODY MASS INDEX IGA BIOPSY CASE-CONTROL STUDIES FOLLOW-UP STUDIES |