| Author/Editor | Margić, Krunoslav | |
| Title | Cijeljenje povrijeđenih malih žila | |
| Type | monografija | |
| Place | Rijeka | |
| Publisher | Sveučilište "Vladimir Bakarić", Medicinski fakultet | |
| Publication year | 1990 | |
| Volume | str. 99 | |
| Language | cro | |
| Abstract | Rat femoral vessels were subjected to simple dissection, clamping and "milking" patency test. The vessels were examined in longitudinal sections by light microscopy at intervals ranging from one day to three months. Simple dissection was followed by partial loss of smoth muscle cells in thinned and stretched media. With injury of media the intensified intraluminal pressure has been transmitted to tunica adventitia causing tightening and crowding of the remaining fibrous bundles. This forms a dense fibrous layer which protects the integrity of injured vessel walls. Regeneration has started simultaneously in all layers. Soon after injury cellular and capilary multiplication was seen in vasa vasorum followed by their longitudinal proliferation over densed adventitia. On the seventh day direct connections between neoadventitia and surrounding granulating tissues have been found. While only the outer layer of adventitia in dissected vessels was invaded by neovasa, in clamped and "milked" segments the whole adventitia was invaded by new fibrous tissue which strongly adhered to surroundings. Exhausting dissection through adhered neoadventitia carries a risk of new dangerous injuries of vessel walls. Multiplication of smooth muscle cells has started soon after injury. While in mild lesions, such as ischemic areas and shallow ruptures, regeneration has been found, deep ruptures have been filled with cicatrix formed by longitudinally oriented smooth muscle cells and elastic tissue. When roughly made "milking" patency test has provoked catastrophic changes, such as deep ruptures, internal flaps and in some cases distal invagination of avulsed media. Hyperplasia of smooth muscle cells has been found almost exclusively in clamped and "milked" segments. It first started in well preserved segments of media, adjacent to great deformations of intraluminal surface and where the greatest turbulence of flow is to be expected. (Abstract truncated at 2000 characters) | |
| Descriptors | FEMORAL ARTERY DISSECTION TUNICA MEDIA WOUND HEALING REGENERATION ENDOTHELIUM, VASCULAR RATS |