Author/Editor		Bračko, Matej
Title		Gastrointestinalni stromalni tumor (GIST): biološke, patološke in klinične značilnosti
Translated title		Gastrointestinal stromal tumors: biologic, pathologic and clinic characteristics
Type		članek
Source		In: Omejc M, Repše S, editors. Zbornik simpozija Kirurgija želodca - standardi in novosti; 2005 okt 13-15; Ljubljana. Ljubljana: Klinični oddelek za abdominalno kirurgijo, Klinični center,
Publication year		2005
Volume		str. 91-7
Language		slo
Abstract		Gastrointestinal stromal tumor (GIST), the most common mesenchymal tumor of the gastrointestinal tract, is a distinct tumor entity, different from smooth muscle and nerve sheath tumors of the digestive system. GISTs are characterized by the expression of CD117/KIT, which can be detected by immunohistochemistry. The identification of mutations of KIT protooncogene in many GISTs has resulted in a better understanding of their oncogenic mechanisms. Since an effective specific biologic treatment is now available, the diagnosis of GIST must be accurate. This paper briefly reviews the biological, pathological and clinical features of GIST.
Descriptors		GASTROINTESTINAL NEOPLASMS MESENCHYMOMA PROTO-ONCOGENE PROTEINS C-KIT IMMUNOPHENOTYPING STOMACH NEOPLASMS IMMUNOHISTOCHEMISTRY