Author/Editor		Ogrinc, Katarina
Title		Zdravljenje bolnikov s kronično lymsko boreliozo
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2005
Volume		str. 138
Language		slo
Abstract		Lyme borreliosis is a tick-transmitted infectious disease, caused by Borrelia burgdorferi sensu lato. It is endemic in Slovenia. Skin, joints, the nervous system and heart are most often affected. Diagnosis of Lyme borreliosis is established upon epidemiological features, clinical presentation and laboratory findings. Borrelial etiology of the late form of the disease is usually proved by serologic tests, but interpretation of results is sometimes difficult, especially in endemic regions. Patients with Lyme borreliosis are treated with oral or pareneteral antibiotics. When the central nervous system is suspected to be involved, ceftriaxone should be chosen. Therapy for Lyme borreliosis is well defined only for early manifestations of the disease. There are many obscurities when late forms of Lyme borreliosis are considered. Clinical and diagnostic criteria are poorly defined and there are no therapeutic guidelines. Recommendations for the treatment of early Lyme borreliosis are followed, although we have no proof that this is the optimal treatment regimen for chronic patients. The number of such patients is relatively small and the number of studies considering this problem is limited, especially in Europe. Patients with chronic Lyme borreliosis often have unspecific symptoms such as headache, concentration or sleep disturbances, and vertigo. Because the central nervous system involvement of borrelial infection is assumed even when they do not exlubit clinically overt neurological signs, they are often treated with courses of i. v. ceftriaxone. The duration of treatment is as a rule at least 2 weeks or longer. This treatment approach is usually associated with visits to the hospital or an outpatient health-care unit every day, and has potentially severe side effects. (Abstract truncated at 2000 characters)
Descriptors		LYME DISEASE BORRELIA BURGDORFERI IGM IGG DOXYCYCLINE CHRONIC DISEASE CEFTRIAXONE CEREBROSPINAL FLUID PROTEINS