Author/Editor		Bergauer, Andrej; Dajčman, Davorin
Title		Osnove jetrne ciroze
Translated title		Basic concepts of liver cirrhosis
Type		članek
Source		Med Mes
Vol. and No.		Letnik 2, št. 1
Publication year		2006
Volume		str. 14-22
Language		slo
Abstract		Cirrhosis of the liver is unimorphous morphological response of liver tissue to chronic and sustained injury. Clinical presentation depends on sequelae of hepatic parenchimal failure, portal hypertension and pathophysiological mechanisms that are set into action by them the etiological origin of injury being less important. Almost all organ systems are affected by pathophysiological mechanisms that are set into action. When severe hepatic parenchimal failure is clinically apparent and causes complications of liver cirrhosis, current therapies other than liver transplantation have little impact on mortality rates. Most of the current therapeutic interventions is hence directed on prevention and treatment of portal hypertension as well as its complications.
Summary		Jetrna ciroza je morfološko enoten odgovor jetrnega parenhina na kronično in ponavljajočo se okvaro. Ne glede na etiološki izvor kvarnega dejavnika je klinična slika odvisna od posledic odpovedovanja jetrnega parenhima, pojava portalne hipertenzije ter patofizioloških mehanizmov, ki ju spremljajo. Patofiziološki mehanizmi, ki se vzpostavijo, posegajo v delovanje praktično vseh organskih sistemov. Zapleti jetrne ciroze so tesno povezani z njimi. Ko huda jetrna sintetska odpoved povzroča klinično izražene zaplete jetrne ciroze, so terapevtske možnosti izjemno omejene, le presaditev jeter zaenkrat bistveno podaljša življenje in zniža umirljivost. Večina terapevtskih ukrepov je tako usmerjena k preprečevanju in zdravljenju portalne hipertenzije in s tem zapletov, pri katerih pomembno sodeluje.
Descriptors		LIVER CIRRHOSIS HYPERTENSION, PORTAL ESOPHAGEAL AND GASTRIC VARICES GASTROINTESTINAL HEMORRHAGE