Author/Editor     Zorc-Pleskovič, Ruda; Teran, Nataša; Pleskovič, Aleš; Milutinović, Aleksandra
Title     Deletion/deletion genotype of angiotensin-I converting enzyme gene is not associated with coronary artery disease in Caucasians with type 2 diabetes
Type     članek
Source     Coll Antropol
Vol. and No.     Letnik 29, št. 1
Publication year     2005
Volume     str. 149-52
Language     eng
Abstract     In this study we analyzed the contribution of genetic variability of the insertion/deletion (I/D) polymorphism of the angiotensin-I converting enzyme (ACE) gene to the predisposition for coronary artery disease (CAD) in a group of patients with type 2 diabetes. The I/D ACE gene polymorphism was tested in 366 Caucasians with type 2 diabetes: 148 cases with CAD and 218 subjects with no history of CAD. We failed to demonstrate that the ACE DD genotype was a risk factor for CAD in Caucasians with type 2 diabetes (OR 2.0, 95% CI 0.9-4.7; p=0.1). In conclusions, we provide evidence that the ACE deletion/deletion genotype is not risk factor for CAD in Caucasians with type 2 diabetes .
Descriptors     CORONARY ARTERIOSCLEROSIS
DIABETES MELLITUS, NON-INSULIN-DEPENDENT
PEPTIDYL-DIPEPTIDASE A
POLYMORPHISM (GENETICS)
MIDDLE AGE
AGED
SEX FACTORS
GENE DELETION
GENOTYPE
EUROPE