Author/Editor | Zorc-Pleskovič, Ruda; Teran, Nataša; Pleskovič, Aleš; Milutinović, Aleksandra | |
Title | Deletion/deletion genotype of angiotensin-I converting enzyme gene is not associated with coronary artery disease in Caucasians with type 2 diabetes | |
Type | članek | |
Source | Coll Antropol | |
Vol. and No. | Letnik 29, št. 1 | |
Publication year | 2005 | |
Volume | str. 149-52 | |
Language | eng | |
Abstract | In this study we analyzed the contribution of genetic variability of the insertion/deletion (I/D) polymorphism of the angiotensin-I converting enzyme (ACE) gene to the predisposition for coronary artery disease (CAD) in a group of patients with type 2 diabetes. The I/D ACE gene polymorphism was tested in 366 Caucasians with type 2 diabetes: 148 cases with CAD and 218 subjects with no history of CAD. We failed to demonstrate that the ACE DD genotype was a risk factor for CAD in Caucasians with type 2 diabetes (OR 2.0, 95% CI 0.9-4.7; p=0.1). In conclusions, we provide evidence that the ACE deletion/deletion genotype is not risk factor for CAD in Caucasians with type 2 diabetes . | |
Descriptors | CORONARY ARTERIOSCLEROSIS DIABETES MELLITUS, NON-INSULIN-DEPENDENT PEPTIDYL-DIPEPTIDASE A POLYMORPHISM (GENETICS) MIDDLE AGE AGED SEX FACTORS GENE DELETION GENOTYPE EUROPE |