Author/Editor		Pokorn, Dražigost; Hlastan-Ribič, Cirila; Cerar, Anton
Title		Gastric content of the liquid test meals in rats with gastrointestinal neoplasias induced by N-methyl-N-nitrosoguanidineand 1,2-dimethylhydrazine
Type		članek
Source		Int J Cancer
Vol. and No.		Letnik 2, št. 1
Publication year		2006
Volume		str. 19-30
Language		eng
Abstract		We hypothesized that liquid test meal without a calorific value injected directly into the rats stomach by a sonde, may be emptied from the stomach both with and without gastrointestinal tumours at different rate. We tested hypothesis using the dye dilution test for gastric emptying. Intestinal tumours (adenoma, adenocarcinoma) in male Wistar rats at different dieting regime were experimentally induced by 1,2-dimethylhydrazine (DMH). Gastric and duodenal tumours in male Wistar rats at different dieting regime were experimentally induced by N-methyl-N-nitrosoguanidine (MNNG). We noticed statistically higher gastric content after applicating the test meal in the stomach of rats with duodenal tumours in comparison with the group of rats both with gastric tumours (p<0.01) or without gastric tumours (p<0.001). Remained gastric content of rats tested with intestinal tumours was not statistically significant in comparison with remained gastric content of rats with (p= 0.901) or without gastric tumours (p= 0.406). We postulate that the role of duodenal resistance in controlling liquid gastric emptying in rats has principle importance if the test meal is instillated into the stomach with or without tumours through a tube. The tumours of colon have no any effect on the stomach, particularly on gastric emptying of liquid meals instillated in rat stomach. Only duodenal tumours and duodenal pathohistological changes interfered gastric emptying.
Descriptors		STOMACH NEOPLASMS DUODENAL NEOPLASMS METHYLNITRONITROSOGUANIDINE DIMETHYLHYDRAZINES GASTRIC EMPTYING INTUBATION, GASTROINTESTINAL AUTOPSY PHENOLSULFONPHTHALEIN WEIGHT GAIN RATS, WISTAR