Author/Editor		Stokin, Gorazd B; Goldstein, Lawrence SB
Title		Axonal transport and Alzheimer's disease
Type		članek
Source		Ann Rev Biochem
Vol. and No.		Letnik 75
Publication year		2006
Volume		str. 607-27
Language		eng
Abstract		In contrast to most eukaryotic cells, neurons possess long, highly branched processes called axons and dendrites. In large mammals, such as humans, some axons reach lengths of over 1 m. These lengths pose a major challenge to the movement of proteins, vesicles, and organelles between presynaptic sites and cell bodies. To overcome this challenge axons and dendrites rely upon specialized transport machinery consisting of cytoskeletal motor proteins generating directed movements along cytoskeletal tracks. Not only are these transport systems crucial to maintain neuronal viability and differentiation, but considerable experimental evidence suggests that failure of axonal transport may play a role in the development or progression of neurological diseases such as Alzheimer's disease.
Descriptors		ALZHEIMER'S DISEASE AXONS AXONAL TRANSPORT AGING AMYLOID BETA-PROTEIN PRECURSOR TUBULIN NEUROFIBRILLARY TANGLES