Author/Editor		Besednjak-Kocijančič, Lilijana
Title		Zdravljenje otrok z astmo z enim ali dvema dnevnima odmerkoma inhalacijskega kortikosteroida: ocena učinkovitosti zdravljenja in vpliva na rast otrok
Translated title		Once-daily or twice-daily delivery of inhaled corticosteroids: assessment of the efficacy and of influence of the long term treatment on growth in asthmatic children
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 75, št. 3
Publication year		2006
Volume		str. 163-7
Language		slo
Abstract		Background Inhaled corticosteroids are recommended drugs for asthma treatment. Their growth suppressive potential is well-known. Twice-daily delivery is usually used in children, but poor compliance of such long-term treatment may represent a problem which can be resolved with once-daily regimen. The aim of this prospective study was to asses the efficacy and the influence on growth of long term once-daily administration of inhaled fluticasone propionate (FP) in asthmatic Slovene children under 5 years. Methods Children with mild persistent asthma took part in parallel group trial. Their parents recorded asthma symptoms, beta2-agonist usage, and PEF using a form for asthma control on a daily basis for a period of one year. According twice or once-daily treatment they were divided in two groups: group A - children receiving FP 100microg twice-daily and group B children receiving FP 200microg once-daily at bedtime. Mean height of 26 children of the same sex and age from each group and of 26 healthy children (groups A1, B1, C) was observed. Chi-square analysis with Yates' correction and t tests were employed for between - group analyses (SPSS software 11.0). Results FP given once-daily was as effective and tolerated as the same total dose given twice-daily. PEF, asthma symptoms and bronchodilator use of children from group B were not significantly different from those from group A (p > 0. 05). The mean height increase of children receiving FP once-daily was smaller for 0.22 cm than of children receiving FP twice-daily and for 0.98 cm than of healthy children (t = Z.56 p = 0. Z32; DF: 24). Conclusions Once-daily administration of inhaled FP in asthmatic children is safe and as effective as twice-daily administration. The suppressive potential is greater when it is given once-daily.
Summary		Izhodišča Inhalacijski glukokortikoidi (IGK) so kljub vplivu na rast varni za zdravljenje astme pri otroku. Za preventivno zdravljenje običajno priporočamo dva odmerka IGK dnevno, kar ob dolgotrajnem zdravljenju lahko vpliva na sodelovanje staršev zlasti tistih otrok, pri katerih bolezen miruje. S prospektivno raziskavo smo želeli ovrednotiti učinkovitost zdravjenja vzorca slovenskih otrok z astmo, mlajših od 5 let, z dvema ali pa z enim dnevnim odmerkom flutikazon propionata (FP) in vpliv slednjega na rast. Metode V raziskavo so bili vk jučeni otroci z blago persistentno astmo. Njihovi starši so vsak dan beležili simptome astme, porabo olajševalca in največji pretok zraka v izdihu (PEF). v skupini A so bili otroci, ki so dvakrat dnevno vdihovali po 100microg FP, v skupini B pa otroci, ki so vdihovali 200microg FP enkrat dnevno. Spremljali smo rast 26 otrok istega spola in starosti iz vsake skupine ter 26 zdravih otrok (skupine: A1, B1, C). Za potrditev razlik med skupinami sta bila uporabljena x2 test in t-parni test (P.C; SPSS 11.0). Rezultati Zdravljenje z enim odmerkom FP je bilo enako učinkovito kot zdravljenje z enakim od merkom zdravila, razdeljenem na dva odmerka. Med skupinama A in B ni bilo statistično značilnih razlik v PEF, simptomih astme in porabi olajševalca (p > 0,05). Povprečna telesna višina otrok, zdravljenih z enim odmerkom FP, je bila nižja za 0,22 cm od telesne višine otrok, zdravljenih z dvema odmerkoma, in za 0,98 cm od telesne višine zdravih otrok (t = 1,56 p = 0,132; DF: 24). Zaključki Zdravljenje z enim dnevnim odmerkom FP je varno in enako učinkovito kot z dvema. Zastoj rasti je ob tem zanemarljivo večji.
Descriptors		ASTHMA GLUCOCORTICOIDS, SYNTHETIC ADMINISTRATION, INHALATION BODY HEIGHT PEAK EXPIRATORY FLOW RATE CHILD