Author/Editor		Cevc, Matija
Title		Lipidi in rak - soodvisnost? Vpliv hipolipemikov in indikacije za njihovo uporabo pri rakavih bolnikih
Type		članek
Source		In: Kozak M, Blinc A, Šabovič M, editors. Žilne bolezni in rak; 2006 apr; Šmarješke toplice. Ljubljana: Združenje za žilne bolezni,
Publication year		2006
Volume		str. 169-76
Language		slo
Abstract		Low serum cholesterol has been associated with increased risk of cancer mortality. Detailed analyses of cancer epidemiology indicate that low serum cholesterol is not the cause of cancer but can be attributed to preexisting cancer. Large prospective randomized studies demonstrated that treatment with statins caused significant reduction in overall and cardiovascular mortality and did not increase nonvascular mortality. Lowering total cholesterol does not produce adverse effect on cancer incidence. It was shown that statins can even reduce the risk of cancer but the results are not conclusive; it is assumed that statins have in general neutral effect on cancer and cancer death risk. Statins have pleotropic effects on many essential cellular functions by interfering with Ras and Rho protein family. Statins induce apoptosis of tumor cells and influence cell proliferation, migration and angiogenesis by interfering with predication of Ras and Rho proteins. The results of studies suggest that statins could effectively strengthen the therapeutic activity of chemotherapeutics. However, at the moment it is to soon to advice any combination of anticancer therapy and statins.
Descriptors		NEOPLASMS CHOLESTEROL NEOVASCULARIZATION, PATHOLOGIC HYDROXYMETHYLGLUTARYL COA REDUCTASES APOPTOSIS