Author/Editor		Krevel, Barbara; Šabovič, Mišo
Title		Tromboza in rak: patofiziologija hiperkoagulabilnega stanja pri bolnikih z malignim obolenjem
Type		članek
Source		In: Kozak M, Blinc A, Šabovič M, editors. Žilne bolezni in rak; 2006 apr; Šmarješke toplice. Ljubljana: Združenje za žilne bolezni,
Publication year		2006
Volume		str. 185-91
Language		slo
Abstract		Thrombosis is a relatively common complication in patients with malignancies. In recent years there has been a growing amount of data regarding the mechanisms of thrombosis formation, especially in regard with the pathophysiology of the hypercoagulable state. Almost all types of cancer cells have the ability to activate the coagulation system with production and secretion of procoagulants and proinflammatory cytokines and by direct interactions with endothelial cells, monocytes/macrophages and platelets. Other mechanisms of coagulation activation include nonspecific factors, such as generation of acute phase reactants and necrosis, aberrant protein metabolism and haemodynamic compromise (stasis). The prothrombotic tendency is further increased by anticancer therapy (surgery, chemotherapy, hormone therapy, central venous catheters).
Descriptors		NEOPLASMS THROMBOEMBOLISM