| Author/Editor | Radovancevic, Branislav; Konuralp, Cuneyt; Vrtovec, Bojan; Radovancevic, Rajko; Thomas, Cynthia D; Zaqqa, Munir; Vaughn, William K; Frazier, OH | |
| Title | Factors predicting 10-year survival after heart tranplantation | |
| Type | članek | |
| Source | J Heart Lung Transplant | |
| Vol. and No. | Letnik 24, št. 2 | |
| Publication year | 2005 | |
| Volume | str. 156-9 | |
| Language | eng | |
| Abstract | Background: We sought to identify factors predictive of long-term (> 10-year) survival in heart transplant (HTx) recipients. Methods: Four hundred fifteen adult patients underwent HTx at our institution between Augvst 1982 and May 1997. The 158 patients who survived >10 years (Group A) and the 116 patients who died between 2 and 6 years (Group B) of HTx were compared in terms of gender, gender mismatch, ethnicity, age, height, weight, United Network for Organ Sharing status, type of induction therapy (OKT3 or anti-thymocyte globulin), infections (bacterial, viral, fungal and protozoal), cytomegalovirus (CMV) status, CMV mismatch, diabetes mellitus, hypertension and incidence of rejection episodes and transplant coronary artery disease within 2 years of HTx. Results: Group A (135 men, 23 women; mean age 48 ± 11 years) had significantly fewer post-HTx rejection episodes and viral, bacterial, fungal and total infections than did Group B (95 men, 21 women; mean age 49+-12 years). Group A also had a significantly lower mean donor age, a lower incidence of pre-HTx diabetes, and a lower mean cholesterol level 1 year after HTx. In a multivariate analysis, fewer bacterial infections and rejection episodes after HTx, the absence of pre-HTx diabetes, and lower donor age were associated with longer survival. Conclusions: Pre-HTx diabetes, donor age and incidences of infection and rejection within 2 years of HTx predict long-term (> 10-year) survival. Better control of infection and rejection during the first 2 years after HTx may improve survival. | |
| Descriptors | HEART TRANSPLANTATION GRAFT REJECTION INFECTION IMMUNOSUPPRESSIVE AGENTS SURVIVAL ANALYSIS MULTIVARIATE ANALYSIS FOLLOW-UP STUDIES |