Author/Editor		Franić, Damir; Verdenik, Ivan; Meden-Vrtovec, Helena; Švab, Igor
Title		Continuation of hormone replacement therapy in Slovenia: a prospective, randomized, controlled - 1-year follow-up
Type		članek
Source		Maturitas
Vol. and No.		Letnik 54
Publication year		2006
Volume		str. 110-8
Language		eng
Abstract		Objectives: To evaluate the influence of educational intervention on the hormone replacement therapy (HRT) continuation rate in Slovenia after the publication of WHI results. Methods: We enrolled 125 early postmenopausal women in a 12-month prospective, randomized, controlled, multicentric study in Slovenia. The study group women (n = 62) attended educational lectures; the control group women (n = 63) did not. Data were collected from three types of questionnaire: before starting HRT, at follow-up visits at 3, 6, 9 and 12 month, after the educational lecture (study group). The continuation rate was measured on the basis of women's self-reports. The results were analyzed according to the "intention-to-treat" principle. The Cox proportional hazard model was used for the final analysis. Results: A gynecologist's suggestion, climacteric symptoms and quality of life were the prevailing reasons for starting HRT. The prevailing factors affecting continuation of HRT were: no or irregular previous OC use (hazard ratio 3.7), no educational lectures (hazard ratio 2.0) and climacteric disorders as the reason for start HRT (hazard ratio 2.1). In the women who discontinued HRT within the first 3 months, the fear of endometrial cancer, breast cancer and bleeding problems were statistically more significant than other factors (P=0.034). In the women who stopped HRT use within 6-12 months, the fear of breast and endometrial cancers increased substantially (P=0.002). Conclusions: Previous OC use and educational lectures on menopausal problems and HRT significantly improve the HRT continuation rate. The main reason for discontinuing HRT is fear of breast cancer, intensified by media.
Descriptors		ESTROGEN REPLACEMENT THERAPY CLIMACTERIC BREAST NEOPLASMS ENDOMETRIAL NEOPLASMS PATIENT EDUCATION QUESTIONNAIRES SURVIVAL ANALYSIS PROSPECTIVE STUDIES RANDOMIZED CONTROLLED TRIALS