Author/Editor		Blinc, Aleš
Title		Pomen arterijske prekrvitve za celjenje ran
Type		članek
Source		In: Smrke DM, editor. Sodobni pristopi k zdravljenju akutne in kronične rane. Zbornik predavanj 1. simpozij o ranah z mednarodno udeležbo; 2006 jun 2-3; Portorož. Ljubljana: Klinični oddelek za kirurške infekcije,
Publication year		2006
Volume		str. 46-9
Language		slo
Abstract		Adequate arterial perfusion is necessary for successful wound healing, since pronounced hypoxia prevents biosynthesis and cell proliferation. Formation of granulation tissue is accompanied by angiogenesis. Newly formed capillaries provide oxygen and nutrients for the regenerating tissue. In critical limb ischemia obstruction of the arterial macrocirculation leads to dysfunction of the microcirculation, which prevents wound healing and may by itself lead to ischemic ulceration. Treatment of critical limb ischemia most often requires successful arterial revascularization, which is followed by gradual recovery of the microcirculation over the next few weeks. Transcuatneous oxygen tension of s 20 mmHg in the periwound area predicts unsuccessful wound healing, whereas values of >= 40 mmHg predict successful healing.
Descriptors		WOUND HEALING MICROCIRCULATION NEOVASCULARIZATION, PHYSIOLOGIC PERIPHERAL VASCULAR DISEASES ISCHEMIA