Author/Editor		Decock, Julie; Paradaens, Robert; Čufer, Tanja
Title		Proteases and metastasis: clinical relevance nowadays?
Type		članek
Source		Curr Opin Oncol
Vol. and No.		Letnik 17, št. 5
Publication year		2005
Volume		str. 545-50
Language		eng
Abstract		Purpose of review A great deal of breast cancer research has been devoted to the search for new prognostic and predictive markers which could, on the one hand, enable a more precise identification of patients at high risk of recurrence and, on the other hand, predict the response of each individual patient to the administered therapy. Proteases have been the center of interest because of their prominent involvement in cancer progression and metastasis. In particular, the matrix metalloproteinases, the serine protease urokinase plasminogen activator, the cathepsins, and corresponding inhibitors have been studied extensively. This article reviews the developments during the last year in this field. Recent findings The prognostic effect of urokinase plasminogen activator and plasminogen activator inhibitor 1 was confirmed in a meta-analysis and in a prospective randomized clinical study that provided level 1 evidence for the clinical value of these markers. Furthermore, encouraging data suggest that both urokinase plasminogen activator and plasminogen activator inhibitor 1 might be important predictive markers. To date, findings on the prognostic and predictive value of the matrix metalloproteinases, the cathepsins, and their inhibitors are still inconclusive. Summary On the basis of currently available data, tumor urokinase plasminogen activator and plasminogen activator inhibitor 1 levelscould already be used in everyday clinical practice for selection of candidates fot adjuvant systemic therapy: Further effort should be put into the standardization of the matrix metalloproteinases and cathepsins determination so that their clinical relevance in breast cancer can be defined.
Descriptors		BREAST NEOPLASMS NEOPLASM RECURRENCE, LOCAL NEOPLASM METASTASIS PROGNOSIS PREDICTIVE VALUE OF TESTS METALLOPROTEINASES CATHEPSINS PLASMINOGEN ACTIVATOR INHIBITOR 1 UROKINASE DISEASE-FREE SURVIVAL