| Author/Editor | Župunski, Ana | |
| Title | Vloga različnih dopplerskih preiskav pri ugotavljanju zožitve ledvične arterije presajene ledvice | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2005 | |
| Volume | str. 94 | |
| Language | slo | |
| Abstract | BACKGROUND: Transplant renal artery stenosis (TRAS) is a relatively frequent and potencially correctable cause of posttransplantation hypertension and/or deterioration of renal function and graft loss. The golden standard for diagnosing TRAS is still renal angiography. Duplex-Doppler sonography enables noninvasive, but accurate screening and follow-up of TRAS. The aim of our three prospective clinical studies was to evaluate the use of duplex-Doppler sonography of the transplant renal artery, captopril-Doppler and losartan-Doppler sonography for the diagnosis of transplant renal artery stenosis. The following HYPOTHESES were verified: l. Duplex-Doppler examination of the transplant renal artery reveals transplant renal artery stenosis with respect to a peak systolic velocity, higher than 1.8 m/s. 2. Increased end-diastolic velocity at the site of stenosis is a good predictor of significant stenosis. 3. Prolonged acceleration time at the level of intrarenal arteries is a good additional criterion of significant stenosis. 4. Decreased resistance index at the level of intrarenal arteries is not a good predictor of significant stenosis. 5. A captopril-Doppler examination reveals significant transplant renal artery stenosis. 6. A losartan-Doppler examination reveals significant transplant renal artery stenosis. SUBJECTS AND METHODS: Study 1: 19 renal transplant recipients, 6 females and 13 males, aged 39 ± 13 years, with renal transplant artery stenosis on duplex-Doppler examination, were included in the study. The Doppler criterion for diagnosing stenosis was peak systolic velocity (PSV > 1.8 m/s). The control group was comprised of 18 renal transplant recipients, 10 females and 8 males, aged 39 ± 13 years, without renal transplant artery stenosis on duplex-Doppler examination (PSV < 1.5 m/s). All patients from the stenosis group also underwent magnetic resonance angiography with gadolinium (MRA). (Abstract truncated at 2000 characters) | |
| Descriptors | KIDNEY TRANSPLANTATION RENAL ARTERY OBSTRUCTION GRAFT OCCLUSION, VASCULAR MAGNETIC RESONANCE ANGIOGRAPHY CAPTOPRIL GADOLINIUM |