| Author/Editor | Šmid, Lojze M; Vovko, Tomaž D; Popović, Mara; Petrič, Andrej; Kepe, Vladimir; Barrio, Jorge R; Vidmar, Gaj; Bresjanac, Mara | |
| Title | The 2,6-disubstituted naphthalene derivative FDDNP labeling reliably predicts Congo red birefringence of protein deposits in brain sections od selected human neurodegenerative diseases | |
| Type | članek | |
| Source | Brain Pathol | |
| Vol. and No. | Letnik 16 | |
| Publication year | 2006 | |
| Volume | str. 124-30 | |
| Language | eng | |
| Abstract | Deposition of conformationally altered proteins prominently characterizes pathogenesis and pathomorphology of a number of neurodegenerative disorders.2(7-[6-[(2-[F-18]fluoroethyl) (methypamino]-2-naphthyl] ethylidene) malononitrile ([F78]FDDNP], a hydrophobic, viscosity-sensitive, solvent-sensitive, fluorescent imaging probe has been used with positron emission tomography to visualize brain pathology in the living brain of Alzheimer disease (AD) patients.lts non-radiofluorinated analog FDDNP was shown to label senile plaques and neurofibrillary tangles (NFTs) in brain tissue sections. This work aimed at evaluating FDDNP labeling of various protein deposits in fixed, paraffin-embedded brain tissue sections of selected neurodegenerative disorders: AD, cerebral amyloid angiopathy (CAA), transmissible spongiform encephalopathies, progressive supranuclear palsy (PSP), Pick disease (PiD), Parkinson disease, dementia with Lewy bodies, multiple system atrophy (MSAI. Cerebral hypertensive vascular hyalinosis (HVH) was used as negative control. Significant agreement between amyloid histochemical properties and FDDNP labeling of the deposits was established. FDDNP labeling showed high positive predictive value for birefringence in senile plaques and NFTS in AD, prion plaques and amyloid deposits in CAA. No FDDNP labeled structures were observed in HVH, PSP, PiD or MSA tissue sections.0ur findings may be of significant value for the detection of neuropathological aggregates with [F-18]FDDNP in some of these disorders in the living brain of human subjects. | |
| Descriptors | NAPHTHALENES ALZHEIMER'S DISEASE AMYLOID BETA-PROTEIN CEREBRAL AMYLOID ANGIOPATHY PRION DISEASES TOMOGRAPHY, X-RAY COMPUTED NEUROFIBRILLARY TANGLES PROTEIN CONFORMATION SUPRANUCLEAR PALSY, PROGRESSIVE DEMENTIA LEWY BODIES BRAIN DISEASES HISTOCYTOCHEMISTRY |