Author/Editor		Kolman, Jana; Gubina, Marija
Title		Sodelovanje Slovenije v projektu EARSS
Translated title		Participation of Slovenia in the EARSS project
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 45, št. Suppl 2
Publication year		2006
Volume		str. 3-10
Language		slo
Abstract		The results of monitoring antimicrobial resistance among invasive isolates from patients in Slovenia during the European Antimicrobial Resistance Surveillance System (EARSS) project are presented. From the second half of 2000 till the end of 2004, 4028 first isolates per patient per year from blood cultures and cerebrospinal fluids were included in the EARSS database after removing any duplicate records on a quarterly and yearly basis. Out of these, 1346 isolates of Staphylococcus aureus, 635 of Streptococcus pneumoniae (51 from cerebrospinal fluids), 1781 of Escherichia coli (4 from cerebrospinal fluids) and 266 isolates of enterococci (Enterococcus faecalis and E. faecium) were included. A decrease in MRSA isolates was observed: from 21.4% in the year 2000 to 11.8% in 2004. In twelve Slovene hospitals, the proportions of MRSA were from 7.7% (39 isolates) to 25% (48 isolates). In S. pneumoniae isolates, the proportion of penicillin non-susceptible isolates decreased from 22.5% in 2000 to 14.5% in 2003, and then increased back to 25.3% in 2004. Highly penicillin-resistant isolates were detected in 1% of cases in 2002 and in 2.4% in 2004. Out of 166 isolates of S. pneumoniae in 2004, 13 (7.8%) had dual penicillin and erythromycin resistance, 29 (17.5%) single penicillin and 6 (3.6%) single erythromycin resistance. In a four year follow-up, 63.3% (1127) of invasive isolates of E. coli were reported in patients aged 65 years or over. In this age group, the proportion of ciprofloxacin resistance was 12.7%. 17 out of 1781 (1%) isolates were extended-spectrum beta-lactamase (ESBL) positive. E. faecalis was the predominant isolate among enterococci in all four years with the 68.4% proportion. An increase in the proportion of E. faecium from 25.9% in 2000 to 37.4% in 2004 was also observed. No vancomycin-resistant enterococci were reported.
Summary		Prispevek prikazuje rezultate spremljanja odpornosti nekaterih invazivnih bakterij pri bolnikih v Sloveniji v okviru projekta EARSS (angl. European Antimicrobial Resistance Surveillance System). Od druge polovice leta 2000 do konca leta 2004 je bilo iz Slovenije v podatkovno bazo EARSS, po izključitvi četrtletnih in letnih dvojnikov, vključenih skupaj 4028 prvih izolatov iz krvi ali likvorja. Od teh je bilo 1346 izolatov Staphylococcus aureus, 635 izolatov Streptococcus pneumoniae (51 iz likvorja), 1781 izolatov Escherichia coli (4 iz likvorja) in 266 izolatov enterokokov (Enterococcus faecalis in E. faecium). Delež MRSA med izolati S. aureus se je z 21,4% leta 2000 znižal na 11,8% v letu 2004. V dvanajstih slovenskih bolnišnicah je bil skupni delež MRSA od 7,7% (39 izolatov) do 25% (48 izolatov). Med izolati S. pneumoniae se je delež proti penicilinu odpornih znižal z začetnih 22,5% leta 2000 na 14,5% v letu 2003, a je v letu 2004 porasel na 25,3%. Proti penicilinu visoko odporne pnevmokoke smo zaznali v letu 2002 v 1%, v letu 2004 jih je bilo 2,4%. Med skupaj 166 izolati S. pneumoniae v letu 2004 je bilo 13 (7,8%) sočasno opornih proti penicilinu in eritromicinu, 29 (17,5%) le proti penicilinu in 6 (3,6%) le proti eritromicinu. Med vsemi invazivnimi izolati E. coli v štiriletnem obdobju je bilo kar 63,3 % (1127) vseh osamljenih pri bolnikih, starih 65 in več let. V tej starostni skupini je bil delež proti ciprofloksacinu odpornih izolatov 12,7%. Pri 17/1781 (1%) izolatih so bile odkrite laktamaze beta z razširjenim spektrom delovanja (ESBL). Med enterokoki iz hemokultur je v vseh obdobjih prevladoval E, faecalis s skupnim 68,4 % deležem. Opazno je bilo povečanje deleža E. faecium s 25,9% leta 2000 na 37,4% v letu 2004. Med prijavljenimi izolati ni bilo nobenega proti vankomicinu odpornega enterokoka.
Descriptors		DRUG RESISTANCE, MICROBIAL STAPHYLOCOCCUS AUREUS ESCHERICHIA COLI ENTEROCOCCUS FAECALIS ENTEROCOCCUS FAECIUM METHICILLIN RESISTANCE MICROBIAL SENSITIVITY TESTS