Author/Editor		Gasparini, Mladen
Title		Periferna arterijska bolezen pri bolnikih z arterijsko hipertenzijo
Translated title		Peripheral artery disease in patients with arterial hypertension
Type		članek
Source		Družinska medicina
Vol. and No.		Letnik 4, št. Suppl 2
Publication year		2006
Volume		str. 81-6
Language		slo
Abstract		The prevalence of peripheral arterial disease in people aged over 55 years is about 20% and increases with age. Most of affected individuals are asymptomatic and only a minority have claudication pain or critical ishemia. Patients with peripheral arterial disease alone have the same relative risk of death from cardiovascular causes as those with coronary or cerebrovascular disease, and are six times more likely to die within 10 years than patients without the disease. About half of patients with peripheral arterial disease (defined by an abnormal ankle-brachilal index) have symptomatic coronary or cerebral vascular disease. The goals of treatment are to prevent future major coronaryand cerebrovascular events and to improve leg symptoms. Noninvasive therapy for intermittent claudication involves risk-factor modification, exercise, and pharmacologic therapy. There is no evidence that any antihypertensive drug could have an advantage over the others in patients with peripheral arterial disease. Beta-blockers could be safely used in mild to moderate disease but caution is recommended in more severe disease.
Summary		Prevalenca periferne arterijske bolezni pri ljudeh starejših od 55 let znaša okoli 20% in narašča s starostjo. Večina bolnikov je brez težav in le manjši delež bolnikov ima klavdikacijske bolečine ali znake kritične ishemije. Bolniki s periferno arterijsko boleznijo imajo enako tveganje za smrt zaradi srčno-žilnih zapletov kot bolniki s prizadetostjo venčnih ali možganskih arterij. V primerjavi z zdravimi vrstniki, umirajo bolniki s periferno arterijsko boleznijo šestkrat pogosteje. Približno polovica bolnikov s periferno arterijsko boleznijo (opredeljeno z znižanim gleženjskim indeksom) ima simptomatsko obliko koronarne ali možgansko-žilne bolezni. Zdravljenje je usmerjeno k preprečevanju srčnih in možganskih zapletov ter izboljšanju simptomov v nogah. Neinvazino zdravljenje bolnikov z intermitentno klavdikacijo zajema zmanjšanje ali odpravo dejavnikov tveganja, redno vadbo in zdravila. Ni dokazov, da ima katera izmed skupin zdravil za zdravljenje arterijske hipertenzije prednost pri bolnikih s periferno arterijsko boleznijo. Tudi blokatorje beta receptorjev lahko uporabljamo pri blagih do zmernih oblikah bolezni, v napredovalih stadijih pa je potrebna previdnost pri predpisovanju.
Descriptors		HYPERTENSION ARTERIAL OCCLUSIVE DISEASES INTERMITTENT CLAUDICATION RISK FACTORS