Author/Editor		Skok, Pavel
Title		Motnje presnove maščob in jetra
Translated title		Disturbed metabolism of lipids and liver
Type		članek
Source		In: Hojs R, Krajnc I, Pahor A, et al, editors. Zbornik predavanj in praktikum 17. srečanje internistov in zdravnikov splošne medicine Iz prakse za prakso z mednarodno udeležbo; 2006 maj 19-20; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2006
Volume		str. 61-70
Language		slo
Abstract		Fatty change or steatosis denotes the excess accumulation of lipids within hepatocytes. The accumulated lipid is predominantly triglyceride, although other lipids may be deposited in certan inherited metabolic disorders or hepatotoxic drug reactions. These abnormal lipids tend to collect in Kupffer cells in addition to hepatocytes. Steatosis generally indicates some disruption of the normal physiology of triglyceride synthesis or secretion but the precise pathogenetic mechamsms are incompletely defined. Potential pathophysiological mechanisms probably include enhanced delivery of fatty acids to the liver from adipose tissue or diet, increased endogenous fatty aad synthesis, decreased mitochondrial fatty acid beta-oxidation and deficient incorporation or export of triglycerides in the form of VLD lipoproteins. In the liver, two basic histological patterns of steatosis are recognized: macrovesicular and microvesicular variety These two patterns appear to represent sequential phases in the accumulation of lipids in the liver The author describes the two histologic patterns of steatosis, their causes and clinical aspects.
Descriptors		FATTY LIVER