Author/Editor		Jančar, N; Rakar, S; Poljak, M; Fujs, K; Kocjan, B J; Vrtačnik-Bokal, E
Title		Efficiency of three surgical procedures in eliminating high-risk human papillomavirus infection in women with precancerous cervical lesions
Type		članek
Source		Eur J Gynaecol Oncol
Vol. and No.		Letnik 27, št. 3
Publication year		2006
Volume		str. 239-42
Language		eng
Abstract		Purpose of investigation: To establish the efficiency of laser vaporization (LV), large loop excision of the transformation zone (LLETZ) and cold knife conization, done for precancerous cervical lesions, in eliminating high-risk human papillomavirus (HPV) infection. Additionally, we determined whether the same HPV genotype persisted after surgery. Methods: A total of 214 women were tested for HPV infection by the Hybrid Cupture II (HCII) test prior to surgery. HPV-positive women were followed by HCII test ten months after surgery. In persistently HPV-positive women, HPV genotypes were determined by PCR - PGMY09/PGMY11. Results: The HCII test showed elimination of HPV infection after LV, LLETZ and cold knife conization in 67.6%, 86,3%, and 100% (p < 0.05) of women, respectively. In seven (38.99%) women a different HPV genotype was found to be present after surgery. The corrected efficiency thus being 79.4%, 92.7% and 100% (p = NS), respectively. Conclusions: The three analyzed surgical procedures are effective in eliminating high-risk HPV infection. HPV testing is useful at follow-up, since it can identify a small proportion of women raquiring close surveillance and potential treatment.
Descriptors		CERVICAL INTRAEPITHELIAL NEOPLASIA PAPILLOMAVIRUS, HUMAN GENOTYPE CONIZATION LASER SURGERY CRYOSURGERY CERVIX NEOPLASMS POLYMERASE CHAIN REACTION