Author/Editor		Sinkovič, Andreja; Marinšek, Martin; Svenšek, Franc
Title		Women and men with unstable angina and/or non-ST-elevation myocardial infarction
Type		članek
Source		Wien Klin Wochenschr Suppl
Vol. and No.		Letnik 118, št. 9-10, Suppl 2
Publication year		2006
Volume		str. 52-7
Language		eng
Abstract		Background: In unstable angina and/or non-ST-elevation myocardial infarction (UA/NSTEMI), sex-related differences in outcomes are less well known than in ST-elevation myocardial infarction (STEMI), where women experience worse outcomes than men. Our aim was a prospective comparison between men and women with UA/NSTEMI of baseline characteristics, inhospital complications, mortality, reinfarctions and combined endpoint of mortality and/or reinfarction during hospital stay, at 30 days and at six months. Methods: Initial medical treatment was given to 92 men and 47 women with UA/NSTEMI. Percutaneous coronary interventions (PCI) were performed within the first 48 hours in cases of recurrent chest pain and/or rhythmic and/or hemodynamic instability. Results: Women were significantly older (66.6±9.6 vs. 59.7±10.6, P=0.0001), less physically active (76.6% vs. 91.3%, P=0.035), with significantly more frequent arterial hypertension (78.7% vs. 51%, P=0.0039) and insulin-treated diabetes (17% vs. 5.4%, P=0.0341), but with less likely prior MI (21.3% vs. 48.9%, P=0.003), smoking (10.6% vs. 32.6%, P=0.009) and dyslipidemia with HDL-cholesterol < 1.0 mmol/L (25.5% vs. 46.4%, P=0.015) than men. Though medical and invasive treatments were similar in both sexes, women were at significantly increased risk of in-hospital pulmonary edema (OR 4.16, 95% CI 1.51 to 11.45) but not at increased risk of adverse in-hospital, 30-day and six-month outcomes in comparison with men. Conclusions: Women with UA/NSTEMI, being significantly older and with more comorbidity, were at significantly increased risk of in-hospital heart failure but not at increased risk of in-hospital, 30-day and six-month adverse outcomes when compared with men, despite their similar treatments.
Descriptors		MYOCARDIAL INFARCTION ANGINA, UNSTABLE ELECTROCARDIOGRAPHY CORONARY CARE UNITS TROPONIN SEX FACTORS ODDS RATIO CHOLESTEROL TRIGLYCERIDES LIPOPROTEINS, HDL CHOLESTEROL LIPOPROTEINS, LDL CHOLESTEROL ASPIRIN HEPARIN