Author/Editor		Ambrožič, Davorin
Title		Prevalenca driske in vpliv antibiotikov na njen pojav v Bolnišnici Golnik
Translated title		Prevalence of diarrhea and impact of antibiotic therapy on its occurence in Golnik hospital
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2006
Volume		str. 40
Language		slo
Abstract		Diarrhea is a change from normal bowel habit. There are many causes of diarrhea, including drugs. Well known causes of diarrhea among drugs are antibiotics, which disrupt the normal human intestinal micro flora. This often leads further to colonization with Clostriduim difficile, gram-positive anaerobic bacteria, which causes diarrhea and pseudomembranous colitis and is health problem of major importance in hospitals in Europe and North America. The goal of our research was to asses the prevalence of diarrhea and impact of antibiotic therapy on the diarrhea occurrence. We also investigated whether there is a specific antibiotic more commonly related to antibiotic-associated diarrhea. For the purposes of this case-control study, diarrhea was detined as three or more loose stools per day. The prevalence of diarrhea was assessed by reviewing the clinical documentation of hospitalized patients in 2005. In addition, ten-week prospective study was carried out in spring 2006. The prevalence of diarrhea in the Golnik hospital is 12.9%. The incidence of diarrhea in spring 2006 is 5.4%. There is no statistically significant relation between diarrhea and antibiotic exposure. Cephalosporinic antibiotics and fluoroquinolones are more commonly associated with diarrhea; however due to a small number of cases, they cannot be statistically identified as a risk factor for antibiotic-associated diarrhea. All episodes of diarrhea were acute and did not have an important effect on patients' hospitalization.
Descriptors		DIARRHEA ANTIBIOTICS HOSPITALIZATION PREVALENCE INCIDENCE