| Author/Editor | Dvoršak, Benjamin | |
| Title | Hiperhomocisteinemija pri bolnikih, ki se zaradi končne ledvične odpovedi zdravijo s hemodializo | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2006 | |
| Volume | str. 48 | |
| Language | slo | |
| Abstract | Background. Cardiovascular disease is major cause of morbidity and mortality in hemodialysis patients. Hyperhomocysteinemia is now recognised as an independent risk factor for cardiovascular disease. Hemodialysis patients have markedly elevated plasma homocysteine levels and hyperhomocysteinemia was found in 75% to 85% of those patients. The aim of the study was to assess the prevalence of hyperhomocysteinemia and to assess possible correlations between serum homocysteine concentrations and serum folic acid and vitamin B12 concentrations in patients treated in our dialysis unit. We aimed to reveal possible correlation between atherosclerotic complications and hyperhomocysteinemia in hemodialysis patients. Patients and methods. A total of 81 patients with end-stage renal disease treated with hemodialysis were included in the study (34 females and 47 males). Mean age was 51,4 years (from 19 to 80 years; SD +- 14,9) and mean duration of dialysis treatment was 54,7 months (from 1 do 236 months; SD +-50,4). Patients taking vitamin medications were excluded. We determined serum concentrations of total homocysteine, folic acid and vitamin B12 (immunoassay, Abbott). We assessed our patients for presence of atherosclerotic complications (ischemic heart disease, stroke and peripheral arterial occlusive disease). The following statistical methods were used for data analysis: arithmetic mean, standard deviation, Student's t-test, Pearson's correlaton coefficient and logistic regression. Results. Mean serum homocysteine concentration was 38,9 mimol/l (from 12,0 to 101,7 mimol/l; SD +- 19,4). (Abstract truncated at 2000 characters) | |
| Descriptors | KIDNEY FAILURE, CHRONIC HEMODIALYSIS HOMOCYSTEINE FOLIC ACID VITAMIN B 12 CORONARY DISEASE CEREBRAL INFARCTION ARTERIAL OCCLUSIVE DISEASES |