Author/Editor		Babnik, Janez; Štucin-Gantar, Irena; Kornhauser-Cerar, Lilijana
Title		Sindrom vnetnega odziva ploda
Translated title		Fetal inflammatory response syndrome
Type		članek
Source		In: Takač I, editor. Mednarodni znanstveni simpozij 40 let perinatalne medicine v Sloveniji; 2006 jun 16; Maribor. Ljubljana: Splošna bolnišnica Maribor,
Publication year		2006
Volume		str. 247-62
Language		slo
Abstract		Background. Numerous studies related intrauterine inflammation to preterm birth and postnatal morbidity. The aim of the study. To determine if fetal inflammatory response syndrome (FIRS) is associated with severe neonatal morbidity. Methods. The prospective study included 125 infants with gestational age 23-29 weeks delivered consecutively in a single tertiary perinatal center. Placental pathology was examined for the presence of chorioamnionitis and funisitis, and cord blood was sampled for the measurement of cytokines (IL-6 and IL-8) with commercial ELISA kits. FIRS was defined as the presence offunisitis orlL-6levels higher than 11 pg/mL. Severe neonatal morbidity included cystic periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH) grade 3 and 4, bronchopulmonary dysplasia (BPD), and early neonatal sepsis. IVH was defined as early if diagnosed within the 1st day after birth; thereafter IVH was defined as late. BPD was defined as any oxygen requirement at 36 weeks postmenstrual age. Perinatal and neonatal data were registered from medical records. Univariate and multivariate logistic regression analyses were performed. Results. Chorioamnionitis with funisitis was associated with significantly increased IL levels in comparison to chorioamnionitis without funisitis (P, < 0.05) and to those withoutplacental inflammation (P <t0.001); Even an incomplete course of antenatal steroids significantly reduced cord hlood levels of IL (P < 0.05). When funisitis was adjusted for the influence of additional variables (gestational age, gender, mode of delivery, and complete course of antenatal steroids), association was found with severe neonatal morbidity (OR Z.6, Z.0 - 2.7, P = 0.04), and early neonatal sepsis (OR 3.2, Z. 7- 5.9, P <0.001) only, but not with PVL, severe IVH, and BPD. (Abstract truncated at 2000 characters)
Descriptors		FETAL DISEASES INFLAMMATION CHORIOAMNIONITIS INTERLEUKIN-8 INTERLEUKIN-6 INFANT, NEWBORN FETAL BLOOD PREGNANCY