Author/Editor		Završnik, Tončka; Burja, Silva; Žebeljan, Ivan
Title		Tokoliza za zdravljenje prezgodnjega poroda: slabosti in prednosti
Translated title		Tocolytic treatment for the management of preterm labor: adverse and beneficial effects
Type		članek
Source		In: Takač I, editor. Mednarodni znanstveni simpozij 40 let perinatalne medicine v Sloveniji; 2006 jun 16; Maribor. Ljubljana: Splošna bolnišnica Maribor,
Publication year		2006
Volume		str. 315-24
Language		slo
Abstract		Objective. To determine the current use of treatment options for preterm labor, to review the relative safety and efficacy of each class of tocolytic agents, and to audit clinical practice at Maribor Teaching Hospital regarding those findings. Materials and methods. Using PERIS (Perinatal Information System) data, a retrospective analysis of premature labors at Maribor Teaching Hospital in 2005 was carried out, and tocolytic treatment was reviewed. The MEDLINE and Cochrane Library were searched using the key words "preterm labor" and "tocolysis". Results. In 2005, in 19% (388) of all delivered women tocolysis had been applied during pregnancy. There were 8.3% of deliveries before 37 weeks, among them 2x triplets and 21x twins. The most often used tocolytic agent was magnesium sulfate in 293 cases, followed by ritodrine in 92 cases. Conclusion. For a relatively small group of women with otherwise uncomplicated preterm labor prior to 34 weeks there appears to be a place for short-term tocolysis. Due to serious maternal side effects, betamimetics are abandoned in favor of nifedipine, which has better neonatal results. Atosiban is also effective, but more expensive. For magnesium sulfate there is evidence of ineffectiveness and concerns about safety. Current clinical practice guidelines should be modified to reflect the current evidence in the literature.
Descriptors		LABOR, PREMATURE TOCOLYSIS TOCOLYTIC AGENTS PREGNANCY