| Author/Editor | Šebeštjen, Miran; Šabovič, Mišo; Eržen, Barbara; Simčič, Saša; Žegura, Branka; Poredoš, Pavel; Keber, Irena | |
| Title | Role of endothelial function and inflammation in patients with cardiovascular risk factors, with and without a history od myocardial infarction | |
| Type | članek | |
| Source | Cardiology | |
| Vol. and No. | Letnik 107, št. 1 | |
| Publication year | 2007 | |
| Volume | str. 1-7 | |
| Language | eng | |
| Abstract | Background: Endothelial dysfunction and inflammation, in particular their lack of improvement after risk reduction, might better reflect advanced atherosclerosis than just the presence of risk factors. The aim ofthis study was to compare endothelial function and inflammatory parameters in highrisk patients who had no history of myocardial infarction and in patients in a stable phase after myocardial infarction. Methods: We compared endothelial function ofthe brachial artery, measured using high-resolution ultrasound, in 45 patients with hyperlipidaemia (Group 1), and in 45 patients in a stable period after myocardial infarction (Group 2). Fortyfive healthy individuals served as a control group (Group 3). ftesults: Compared to patients with treated hyperlipidaemia, patients after myocardial infarction had lower values of total and LDL cholesterol (p = 0.015; 0.005) and homocysteine (p < 0.005), but marginally higher IL-6 levels (p = 0.1). Other measurements were comparable. However, flow-mediated dilation of the brachiai artery was significantly diminished in patients after myocardial infarction (10.6 ± 3.0; 5.9 ± 4.0; 14.0 ± 1.9% for Groups 1-3; ANOVA p = 0.0001; respectively). Conclusions: We found that patients with previous myocardial infarction have substantially lower endothelial function and increased some inflammatory parameters than patients with a similar level of atherosclerotic risk profile but without clinically evident coronary artery disease. | |
| Descriptors | CORONARY DISEASE ENDOTHELIUM, VASCULAR INFLAMMATION BRACHIAL ARTERY HYPERLIPIDEMIA MYOCARDIAL INFARCTION HOMOCYSTEINE LIPOPROTEINS, LDL CHOLESTEROL INTERLEUKIN-6 INTERLEUKIN-8 C-REACTIVE PROTEIN |