| Author/Editor | Wollina, U; Kaatz, M; Kroenert, C; Schoenlebe, J; Schmalenberg, H; Schreiber, G; Koestler, E; Haroske, G | |
| Title | Cutaneous Langerhans cell histiocytosis with subsequent development of haematological malignacies: report of two cases | |
| Type | članek | |
| Source | Acta Dermatovenerol Alp Pannon Adriat | |
| Vol. and No. | Letnik 15, št. 2 | |
| Publication year | 2006 | |
| Volume | str. 79-84 | |
| Language | eng | |
| Abstract | Adult cutaneous Langerhans cell histiocytosis (LCH) is a rare disease. We report two cases illustrating the variability of the clinical presentation and the response to treatment. In both cases a remission was achieved: in one case a partial remission with psoralen plus UVA irradiation (PUVA) and methotrexate plus topical corticosteroid ointment; in the other case by treatment with thalidomide. Despite a therapeutic response, both patients later developed haematological malignancies: a chronic myelo-monocytic leukaemia and an acute lymphatic leukaemia. In conclusion, patients with adult cutaneous LCH should be monitored carefully so that a secondary malignancy is not overlooked. | |
| Descriptors | HISTIOCYTOSIS, LANGERHANS-CELL SKIN MANIFESTATIONS |