Author/Editor		Mišić-Majerus, Liljana; Bujić, Nevenka; Mađarić, Vesna; Avšič-Županc, Tatjana
Title		Hepatitis uzrokovan virusom krpeljnog meningoencefalitisa - rijetka klinička manifestacija izvan središnjeg živčanog sustava
Translated title		Hepatitis caused by tick-borne encephalitis virus (TBEV) - a rare clinical manifestation outside the central nervous system involvement
Type		članek
Source		Acta Med Croatica
Vol. and No.		Letnik 59, št. 4
Publication year		2005
Volume		str. 347-52
Language		cro
Abstract		0bjective: North part of Croatia, especially the Koprivnica-Krizevci County has been a well-known endemic area of tick-borne encephalitis (TBE) for more than 50 years. To date, this disease caused by tick-borne encephalitis virus (TBEV) has retained the leading position among inflammatory diseases of the central nervous system (CNS), with an average morbidity of 19 patients per year. In 88% of patients the infection manifested with signs of meningitis or meningoencephalitis with a biphasic course. TBE may take a more severe course with different neurologic dysfunction or even lethal outcome. There have been isolated reports on some rare clinical manifestations outside CNS involvement caused by TBEV, including transient hepatitis, pancreatitis, and myocarditis. These manifestations have been most frequently detected during the initial stage of disease but also as a complication, or as an individually separate clinical entity. The incidence rate of these manifestations is not known. Until now, such clinical manifestations outside CNS have not been reported ln the county. It was the reason to present the characteristics of Iiver failure in our patients suffering from TBE. Purpose of Work: To determine the frequency of elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in patients with TBEV infection, to nota the time from the detection io disappearance of elevated AST and to investigate and establish whether the degree of liver failure influences the course and outcome of TBE. (Abstract truncated at 2000 characters)
Descriptors		ENCEPHALITIS VIRUSES, TICK-BORNE ENCEPHALITIS, TICK-BORNE HEPATITIS, VIRAL, HUMAN LIVER SEX FACTORS AGE FACTORS ENZYME TESTS