Author/Editor		Blinc, Aleš
Title		Zdravljenje hiperlipidemije pri zelo ogroženih bolnikih
Type		članek
Source		Lekarništvo
Vol. and No.		, št. 1-2
Publication year		2006
Volume		str. 48-53
Language		slo
Abstract		High cardiovascular risk is defined by the Framingham model as >-20% chance of suffering a coronary atherothrombotic event in the next 10 years or by the SCORE model as >-5% chance of suffering a fatal cardiovascular event in the next 10 years. It is appropriate for people at high cardiovascular risk to receive pharmacological prophylaxis in addition to nonpharmacological preventive measures. Antiplatelet therapy, treating hypertension and hyperlipidemia are the mainstay of preventive drug interventions. Statins are the drugs of choice in managing hyperlipidemia in primary and secondary prevention of atherothrombotic disease. In general, a 10% reduction in total serum cholesterol leads to a 20% decrease in atherothrombotic events. More precisely, the relation of LDL cholesterol level and cardiovascular events is log-linear without an "absolutely safe" lower level of LDL cholesterol. Current guidelines for managing patients at high cardiovascular risk and those with overt atherosclerotic disease call for reducing the level of total serum cholesterol to <-4.5 mmol/l and LDL cholesterol to <- 2.5 mmol/l, but even lower levels seem desirable according to recent studies.
Descriptors		HYPERLIPIDEMIA CARDIOVASCULAR DISEASES ANTILIPEMIC AGENTS