Author/Editor		Fiore, S; Antico, G; Aloman, M; Sodin-Šemrl, S
Title		Lipoxin A4 biology in the human synovium: role of the ALX signaling pathways in modulation of inflammatory arthritis
Type		članek
Source		Prostaglandins Leukot Essent Fatty Acids
Vol. and No.		Letnik 73, št. 3-4
Publication year		2005
Volume		str. 189-96
Language		eng
Abstract		Endogenous molecules involved in counterregulation of inflammatory responses provide an opportunity to explore new therapeutic approaches based on manipulation of new pathways that may reduce the possibility of unwanted toxic side effects. Lipoxins (LX) are trihydroxytetraene-containing eicosanoids that are generated within the vascular lumen during cell-cell interactions or at mucosa through leukocyteepithelial cell interactions. Transcellular biosynthetic pathways are the major lipoxin biosynthetic routes where LX are formed in vivo during inflammation and serve as "stop signals" that regulate key steps in leukocyte trafficking. In this review, recent findings in lipoxin generation, impact on the resolution of acute inflammation, and organ protection from neutrophil-mediated injury are presented. Periodontitis, specifically localized aggressive periodontitis, which is recognized as an example of neutrophil-mediated tissue injury, is discussed as a disease model where LX and other endogenous pro-resolution pathway mediators could have potential value.
Descriptors		ARTHRITIS CYTOKINES NF-KAPPA B SIGNAL TRANSDUCTION SYNOVIAL MEMBRANE TRANSCRIPTION FACTOR AP-1 TRANSFORMING GROWTH FACTOR BETA