Author/Editor     Urlep-Šalinović, Vera
Title     Patofiziologija, diagnostika in terapija diseminirane intravaskularne koagulacije
Translated title     Pathophysiology, diagnosis and treatment of disseminated intravascular coagulation
Type     članek
Source     In: Urlep-Šalinović V, editor. Hemostatske motnje. Strokovno srečanje ob 30-letnici hemostaziološke dejavnosti v Splošni bolnišnici Maribor; 2006 maj 26; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year     2006
Volume     str. 115-28
Language     slo
Abstract     Background: Disseminated intravascularcoagulation is thrombohemorrhagic hemostatic disorder occurs most frequent in the following pathological conditions: sepsis, injuries, burns, transfusion of incompatible erythrocytes, massive transfusion, autoimmune diseases, acute promyelocytic and myelocytic leukemia, pancreatitis, in obstetrical complications such as eclampsia, placenta previa, placental abruption, amniotic fluid embolism, HELLP syndrome, retained dead fetus and other complications at the delivery, metastatic malignancy and liver diseases. DIC is a syndrome resulting in multiple organ failure due to mycrovascular thrombosis and severe bleeding due to consumption of coagulation factors and platelets and secondary activation of fibriolysis. The hermostatic tests characteristic for the DIC depending from the step of the activation of coagulation system show slightly or very prolonged prothrombin time, prolonged thrombin time, prolonged activated partial thromboplastin time, decreased fibrinogen, decreased coagulation factors II, V and VIII, decreased antithrombin III, decreased platelets number, increased D-dimer. The hemostatic tests have to be repeat due to quick changes in hemostatic mechanism. By intensive treatment of primary disorder caused DIC we have to stop the thrombotic event using the most suitable anticoagulants (low doses of heparin, low molecular weight heparin, concentrate of AT III, activated PC) and substitute consumed coagulation factors and platelets. Conclusions: DIC is acute and very severe complication in various pathological conditions. Early diagnosis put on clinical symptoms and laboratory findings and good collaboration between clinician and hemostasiologist, leading to intensive treatment may reduce the development of serious complications and mortality.