Author/Editor		Gošnak-Dahmane, Raja; Ribarič, Samo
Title		Celično staranje
Translated title		Cell ageing
Type		članek
Source		Obz Zdrav Nege
Vol. and No.		Letnik 40, št. 2
Publication year		2006
Volume		str. 75-8
Language		slo
Abstract		Ageing can be defined as a progressive failure of body homeostasis in the absence of illness, trauma or their consequences. Age-related-changes are a reduced tolerance to stress, a reduced functional reserve of individual organs and an impaired metabolism of proteins, lipids and carbohydrates, DNA and RNA on a cellular level. The two key challenges of studying age-related-changes are the distinction between cause and effect, and the detection of age-related-changes that have an important impact on life expectancy. In human, the aging process can be attenuated by reducing oxidative stress in the body - by the ingestion of antioxidants or caloric restriction.
Summary		Staranje je postopno odpovedovanje homeostaze v odsotnosti bolezni, poškodbe ali njihovih posledic. Starostne spremembe se prikažejo na celotnem organizmu kot zmanjšana sposobnost preživetja pod stresom, na posameznem organu kot zmanjšana delovna rezerva nato pa kot motena oskrba celega organizma ter na stopnji posamezne celice kot spremenjena hitrost presnove beljakovin, lipidov, ogljikovih hidratov, DNA in RNA. Pomembna problema pri raziskovanju staranja sta: (a) ločevanje vzrokov za starostne spremembe od posledic in (b) kako prepoznati tiste starostne spremembe, ki pomembno vplivajo na dolžino življenjske dobe. Starostne spremembe pri človeku upočasni zmanjšanje oksidativnega stresa organizma z uživanjem antioksidantov ali z omejevanjem vnosa kalorij (kalorično stradanje).
Descriptors		AGING CELL AGING OXIDATIVE STRESS CELL DIVISION APOPTOSIS GENE EXPRESSION