Author/Editor		Matos, T; Haase, G; van den Ende, Gerrits AHG; de Hoog, GS
Title		Molecular diversity of oligotrophic and neurotropic members of the black yeast genus Exophiala, with accent on E. dermatitidis
Type		članek
Source		Antonie Van Leeuwenhoek
Vol. and No.		Letnik 83, št. 4
Publication year		2003
Volume		str. 293-303
Language		eng
Abstract		Analysis of ITS rDNA of the black yeast Exophiala dermatitidis revealed a close phylogenetic relationship to the meristematic fungus Sarcinomyces phaeomuriformis. As most strains of S. phaeomuriformis have a yeast-like phenotype corresponding to the anamorph genus Exophiala, a new combination in Exophiala is proposed. On the basis of ITS sequence, M-13 fingerprint and SSU intron data, two main entities could be distinguished within E. dermatitidis. One of these (B) contained prevalently strains from environmental sources, while the other (A) mainly comprised strains from clinical sources. This may be due to a difference in virulence. All strains from severe brain and disseminated infections in East Asia clustered in group A. However, strains of group A caused a relatively mild fungemia in patients outside East Asia.
Descriptors		BRAIN DISEASES EXOPHIALA MYCOSES VARIATION (GENETICS) FUNGEMIA DNA FINGERPRINTING DNA, FUNGAL DNA, RIBOSOMAL INTRONS MYCOLOGICAL TYPING TECHNIQUES